Discovery of herbicides with new modes of action, new chemistries inspired by antimalarial drugs.Learn more
Protein crystallography of new and known herbicide targets to enable ab initio herbicide design.Learn more
Origins of diverse (often cyclic) plant peptides and the enzymology of their synthesis.Learn more
Are peptide sequences buried in 'host' proteins a type of evolution bypassing the need for a new gene?Learn more
About the Mylne lab at UWA
Our research has two separate foci; applied work on herbicides and fundamental research on biosynthesis and the genetic events that evolve new plant proteins. Our herbicide research aims to find as many new modes of action possible, whereas our more protein evolution work gives insight into biosynthesis and enzymology.
Our applied herbicide work started with our finding that, thanks to the established close evolutionary relationship between plants and the malarial parasites, many antimalarial drugs are also herbicidal. After trawling antimalarial drug libraries for novel herbicide chemistries, we now are focused on discovering novel modes of herbicide action. Our fundamental protein evolution work is based on biosynthesis for different classes of peptides, mostly cyclic ones and many whose sequences are buried in precursors for unrelated proteins. Is this a more universal mechanism for creating new proteins that bypasses the need for a completely new gene?