Discovery of herbicides with new modes of action, new chemistries inspired by antimalarial drugs.

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Protein crystallography of new and known herbicide targets to enable ab initio herbicide design.

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Origins of diverse (often cyclic) plant peptides and the enzymology of their synthesis.

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Are peptide sequences buried in 'host' proteins a type of evolution bypassing the need for a new gene?

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Latest News

Colton Payne leads first paper

Friday, 29 May 2020

Today the first, first-author manuscript for UQ PhD student Colton Payne came out in bioRXiv. It's NMR-centric work on helical hairpin peptides. Colton is based in the Rosengren lab at UQ.

Dr Breese's first day at UWA

Monday, 11 May 2020

Today Dr Karen Breese, an organic synthetic chemist, joined UWA to work on herbicides funded by an ARC DP19. With a PhD from ANU and industry experience at Epichem, she's based in the Stubbs lab. Welcome!

New paper out in JNP

Friday, 3 March 2020

Out today in J. Natural Products led by ex-PhD student Mark Fisher is the paper "Cyclic peptides in seed of Annona muricata are ribosomally synthesized", see it on PubMed or via its DOI.

About the Mylne lab at UWA

Our research has two separate foci; applied work on herbicides and fundamental research on biosynthesis and the genetic events that evolve new plant proteins. Our herbicide research aims to find as many new modes of action possible, whereas our more protein evolution work gives insight into biosynthesis and enzymology.

Our applied herbicide work started with our finding that, thanks to the established close evolutionary relationship between plants and the malarial parasites, many antimalarial drugs are also herbicidal. After trawling antimalarial drug libraries for novel herbicide chemistries, we now are focused on discovering novel modes of herbicide action. Our fundamental protein evolution work is based on biosynthesis for different classes of peptides, mostly cyclic ones and many whose sequences are buried in precursors for unrelated proteins. Is this a more universal mechanism for creating new proteins that bypasses the need for a completely new gene?

Want a closer look?

Check out the active projects in the lab, check out Josh's Twitter feed, see what the lab is publishing or get real and visit us in person! We're always looking for bright minds to join us, get in touch by e-mail!

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