Discovery of herbicides with new modes of action, new chemistries inspired by antimalarial drugs.

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Examining what happens to fungicides once they're inside plants by mass spectrometry.

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Protein crystallography of new and known herbicide targets to enable ab initio herbicide design.

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Origins of diverse (often cyclic) plant peptides and the enzymology of their synthesis.

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Latest News

Nature Comms paper out

Thursday, 22 September 2022

Out today in Nature Communications is our paper on statins, their target HMG-CoA reductase and its potential as a herbicide target. See the article via its DOI, PubMed, this Tweet and we wrote a Behind the Paper article.

HDD2023 registration is open

Tuesday, 6 September 2022

Registration for the 2nd Herbicide Discovery & Development meeting in Perth 18-20 January 2023 and the HDD2023 website are live. A conference ideal for students and ECRs to meet industry and academics interested in herbicides.

Seeding at Marvel Loch

Friday, 20 May 2022

Josh has just finished 12 straight days of seeding out in WA's remote, far-eastern wheat belt. Read about the experience on this CCDM blog, listen to a podcast done on Day 2 or see the series of photo-laden Twitter threads with the hashtags #seeding #MarvelLoch.

About the Mylne lab at Curtin

Our research has two separate foci on two classes of agrochemical; we work to find truly new herbicides and have started to pursue the in planta behaviour of fungicides. Our herbicide research aims to find new herbicides, principally by directing our first efforts at finding and validating new modes of action. Our fungicide work is new since arriving at CCDM in 2021 and seeks to understand biotransformation led by mass spectrometry. We also continue to publish what is quickly becoming legacy work on peptide biosynthesis, protease-mediated cyclisation and the genetic events that evolve new plant proteins.

Our applied herbicide work started with our finding that, thanks to the established close evolutionary relationship between plants and the malarial parasites, many antimalarial drugs are also herbicidal. After trawling antimalarial drug libraries for novel herbicide chemistries, we have turned our focus to discovering novel modes of herbicide action. Our fungicide biotransformation work was inspired by colleagues at CCDM who seek to understand the basis for resistance by pathogens and investigate various means to improve crop health.

Want a closer look?

Check out the active projects in the lab, check out Josh's Twitter feed, see what the lab is publishing or get real and visit us in person! We're always looking for bright minds to join us, get in touch by e-mail!

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